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IgE and IgA antibodies confer protective immunity with resistance to reinfection, and larval killing through antibody-dependent cell-mediated cytotoxicity (ADCC) along with blood effector cells ( Prevention and Treatment Preventive measures are multifaceted and include avoiding contact with infectious water, improved access to uncontaminated water, improved hygiene and sanitation, elimination of intermediate freshwater snail hosts, and provision of health education to high-risk populations, especially in settings with dam construction, irrigation systems, and internally/externally displaced persons (refugee camps) ( Advanced Vaccine Candidates Given the limitations of MDA alone, a hypothesis is that complementing a comprehensive approach with a safe and effective vaccine would more likely be successful in dramatically reducing the incidence of schistosomiasis ( Schistosoma species ( Preferred product characteristics for a schistosomiasis vaccine have been proposed ( For each of the four leading vaccine candidates, we discuss the antigen, and preclinical and clinical studies as applicable
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BioFactors (Oxford, England)
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